"Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". ^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001)."CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". ^ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001).National Center for Biotechnology Information, U.S. Loss of function mutations in CARD11 cause severe combined immunodeficiency (SCID) since the function of cells critical for adaptive immunity are disrupted.ĬARD11 has been shown to interact with BCL10. The phosphorylation induces formation of filamentous CARD11 multimers that recruit BCL10 and MALT1, which in turn activates NF-κB.
After receptor stimulation, CARD11 is phosphorylated by PKC-θ (in T cells) or PKC-β (in B cells). ĬARD11 is critical for T cell and B cell function and is activated after T cell receptor or B cell receptor stimulation. When overexpressed in cells, this protein family activates NF-κB and induces the phosphorylation of BCL10. The CARD domain of proteins in the CARD-CC family have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation by recruitment and activation of MALT1. CARD11 (CARMA1) has a domain structure similar to that of CARD10 (CARMA3) and CARD14 (CARMA2) as a member of the CARD-CC family with a C terminal MAGUK domain (the so-called CARMA proteins). This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain ( CARD). The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. positive regulation of NF-kappaB transcription factor activityĬaspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein in the CARD-CC protein family that in humans is encoded by the CARD11 gene.positive regulation of I-kappaB kinase/NF-kappaB signaling.positive regulation of T cell proliferation.positive regulation of B cell proliferation.positive regulation of T cell activation.stimulatory C-type lectin receptor signaling pathway.positive regulation of cytokine production.